Previous studies in a variety of cancer cell lines as well as solid tumors and hematological malignancies show a unique methylation pattern of TERT. Its promoter region surrounding the TSS [−200 to +100 relative to TSS] is unmethylated, while the upstream promoter region [−650 to −200] is hypermethylated (Figure 1B) (13, 40). The gene discussed is TERT; the disease is cancer.