In support of the TCGA data, in a large study of thyroid cancers in which anaplastic carcinoma coexisted with papillary carcinoma, a multivariate comparison between the antecedent papillary carcinoma components and control papillary carcinomas without anaplastic transformation showed that TERT mutations were independently associated with anaplastic transformation (23). Here, TERT is linked to papillary carcinoma.