There are no significant differences found in clinical pregnancy, ectopic pregnancy, miscarriage, live birth rate, major malformation, neonatal minor malformation, and perinatal death between the toxoplasmosis IgM (–) IgG(+) group and IgM (–) IgG (–) group, which means patients with previous toxoplasmosis infection don't warrant more attention and further treatments. This evidence concerns the gene CD40LG and toxoplasmosis.