Comparably, MetS cases in the general cohort also had a significantly higher incidence of the decrease in semen volume, sperm total count, sperm concentration, sperm normal morphology, sperm progressive motility, FSH, testosterone, and inhibin B. Generally, MetS had the most impact on semen quality and circulating sex hormones of the general cohort, moderate impact on fertile cohort, and the least impact on the infertile cohort. Here, BRD2 is linked to metabolic syndrome.