Animal studies showed that the recovery of brain tissue in ADAMTS13−/− mice was significantly lower than that in wild-type mice at 14 days after ischemic stroke (21) and intraventricular injection of recombinant ADAMTS13 3 h after middle cerebral artery occlusion could reduce tPA-induced hemorrhage by regulating blood brain barrier integrity (13). This evidence concerns the gene PLAT and ischemic stroke.