SAE1 and myositis disease: Serological testing revealed positive titers of anti-nuclear antibodies (ANA) (1:160 vs. <1:40; speckled pattern) and borderline levels of myositis specific antibodies (anti-SAE1, SUMO activating enzyme, and anti-MDA5, CADM-140), however he did not clearly fall into a specific myositis profile, as he had a normal creatine kinase and electromyography (EMG).