GJA1 and ischemic stroke: The destruction of the neuro-glial syncytium structure resulting from the uncoupling of corresponding gap junctions might weaken the mutual support between astrocytes and other cells, and the increase in hemichannel numbers caused by the uncoupling of gap junctions and permeability caused by the dephosphorylation of Cx43 might enhance and spread neuroinflammation and aggravate injury after ischemic stroke.