VPS35 and dysautonomia: Briefly, patients carrying VPS35 mutations had features similar to those with idiopathic PD, with a mean AAO of ~57 years (range: 38–71 years, Table 3): all patients presented the classical triad, with akinesia as the predominant symptom at onset (100%), but a much lower frequency of tremor as an initial symptom (37.5%), a good response to levodopa (100%), with <37% of those treated developing dyskinesias and motor fluctuations, and a low rate of dysautonomia (2/8, 25%), with no cognitive or neuropsychiatric symptoms or atypical signs.