LRRK2 and Parkinson disease: We compared the clinical features of the LRRK2 G2019S+ PD patient (LRRK2+) group with those of PD patients with no mutations of known PD-associated genes, excluding subjects with missing data for the covariables included in the models, such as sex, AAO, and disease duration: 135/151 LRRK2+ and 1,552/1,693 PD patients without mutations were included in the final analysis (Table 4).