PRKN and Parkinson disease: Patients carrying the Ala53Thr mutation had an extra-pyramidal parkinsonian syndrome, but with heterogeneity between patients with the same mutation: Patient 1172-001, with both SNCA Ala53Thr and a heterozygous PRKN Thr240Met variant, had atypical PD, with a poor response to levodopa, early motor fluctuations and cerebellar signs.