MAPT and early-onset autosomal dominant Alzheimer disease: According to this framework the term “Alzheimer's disease” is applied, regardless of the clinical manifestations, whenever there is evidence of pathologic deposits of both Aβ and tau in the brain, as manifested, for example, through AD cerebrospinal (CSF) core biomarkers: Abeta42, phosphorylated Tau (p-tau), and total Tau (t-tau) which reflect amyloid pathology, tau pathology, and neurofibrillary tangle neurodegeneration, respectively.