Starting from the hypothesis of a co-shared vulnerability between impaired glucose tolerance and SSD, detectable in subclinical form even in patients with adolescent onset of psychosis, in our previous study we found higher level of PRL and increase in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in a sample of drug naïve adolescents in the acute phase of first episode psychosis compared to subjects at clinical high risk of developing psychosis (36). The gene discussed is PRL; the disease is Insulin resistance.