IL18 and major depressive disorder: Shifting the focus toward the concentration of specific inflammatory proteins in neuropsychiatric patients, clinical studies found a significant augmentation in the concentration of IL-18 in patients with MDD panic disorder (72), and increased levels of IL-1β in depression and bipolar disorders (73), while TNF-α seems to mediate the production of anorexigenic peptides in anorexia nervosa (74).