NLRP3 and Muckle-Wells syndrome: Mutations in the NLRP3 gene possess clinical relevancy in humans; when occurring in the capsase-1 domain of NLRP3, affected individuals exhibit uncontrolled excretion of IL-1β and IL-18 as part of the autoimmune disorder Muckle-Wells Syndrome, presenting with arthralgia, fatigue, and dermatological pathology (38).