Additionally demonstrated that PDLIM5 plays an important role in the cardiovascular system through miR-mediated regulation of the phenotype of pulmonary artery smooth muscle cells: miR-17∼92 regulates the differentiation of PASMCs through its target PDLIM5, indicating that the miR-17∼92/PDLIM5/TGF-β/Smad pathway is essential for vascular remodeling during the development of pulmonary hypertension. The gene discussed is TGFB1; the disease is pulmonary arterial hypertension.