PDLIM5 and Alzheimer disease: Owusu et al. (2017) found that PDLIM5 gene polymorphism is associated alcohol-dependent (AD), type 2 diabetes (T2D), and hypertension, and Several genetic variants of the PDLIM5 gene can affect AD, T2D and hypertension, indicating that PDLIM5 is a shared gene among the three diseases.