Segmental arterial and afferent arteriolar diameters were not significantly different (Sorensen et al., 2012), but heart weight and afferent wall trans-sectional area were increased in Cx40 KO mice (Sorensen et al., 2012; Jacobsen and Sorensen, 2015), possibly due to the hypertension. Here, GJA5 is linked to Hypertension.