AVE3085 and AVE9488 are small-molecule eNOS enhancers that are protective in rodent models of cardiovascular disease, including heart failure, myocardial infarction and diabetes (Bauersachs and Widder, 2008; Fraccarollo et al., 2008; Wohlfart et al., 2008; Frantz et al., 2009; Schafer et al., 2009; Cheang et al., 2011). Here, NOS3 is linked to cardiovascular disorder.