Under pathological conditions, dysregulation of eNOS activity is involved in cardiovascular disease, vascular aging, vascular dementia and stroke (Huang et al., 1995; Lange-Asschenfeldt and Kojda, 2008; Sawada and Liao, 2009; Toda et al., 2009; Toda, 2012; Zhu et al., 2016; Wang et al., 2018). Here, NOS3 is linked to stroke disorder.