Using data from skeletal muscle biopsies in male subjects, we have shown that certain genes (ACTBL2, BDNF_1, IL8, MYH4) presents similar methylation levels in umbilical cord tissue compared with vastus lateralis biopsies and that methylation in MYL6, OBSCN_4, BDNF_1, and PAX3 can be modified by both, obesity and resistance training. The gene discussed is ACTBL2; the disease is obesity due to melanocortin 4 receptor deficiency.