Furthermore, it was recently shown in vitro that knockdown of Jag1 inhibits the formation of tumor emboli in hybrid E/M inflammatory breast cancer (IBC) – a rare but highly aggressive form of breast cancer that moves largely collectively through clusters (Jolly et al., 2017) – cells SUM149 (Bocci et al., 2019a). This evidence concerns the gene JAG1 and inflammatory breast carcinoma.