Previous work has already presented endothelin-1, as a co-mitogenic factor potentiating growth-promoting effects of other factors (Panettieri et al., 1996) and contributing to pulmonary artery remodeling in pulmonary arterial hypertension (Yang et al., 1999; Maruyama et al., 2015). This evidence concerns the gene EDN1 and pulmonary arterial hypertension.