Circulating chemerin levels were also elevated in chronic inflammatory diseases and states, associated or not with obesity (Kukla et al., 2010; Nakajima et al., 2010) and correlated to systemic levels of pro-inflammatory cytokines, such as TNF-α, IL-6, and C-reactive protein (Lehrke et al., 2009; Weigert et al., 2010). The gene discussed is RARRES2; the disease is obesity due to melanocortin 4 receptor deficiency.