RARRES2 and Hypertension: Initially described as a regulator of energetic metabolism and inflammatory/immune responses (Wittamer et al., 2003; Bozaoglu et al., 2007; Goralski et al., 2007), the adipokine chemerin was identified as a key mediator regulating systemic vascular homeostasis and tone, and contributing therefore to the pathogenesis of hypertension (Watts et al., 2013).