PTK2 and cancer: Because emerging studies have shown that FAK transduces mechanical stress signals to stimulate the activation of the FAK–ERK–MCP-1 signaling pathway and is an important regulator of cancer-promoting pathways (Wong et al., 2011b; Ma et al., 2018), many pharmaceutical companies have taken effort to develop later generation FAK inhibitors that display improved pharmacodynamic and pharmacokinetic properties (Parsons, 2003; Infante et al., 2012).