Evidence of BBB disruption in PD includes the findings of significant increase in albumin and IgG in the cerebrospinal fluid of PD patients (Pisani et al., 2012) and an increase in extravasation of erythrocytes, hemoglobin, and fibrin in the striatum of PD patients (Gray and Woulfe, 2015). The gene discussed is ALB; the disease is Parkinson disease.