NKCC1 protein expression was higher in human glioma cells than in normal control cortex and localized at the leading edge of human glioma cells (Aronica et al., 2007; Haas and Sontheimer, 2010; Garzon-Muvdi et al., 2012; Schiapparelli et al., 2017). Here, SLC12A2 is linked to central nervous system cancer.