A growing body of evidence indicates that expression of NKCC1 protein is closely related to tumor progression, such as lung adenocarcinoma (Sun et al., 2016), prostate cancer cells (Hiraoka et al., 2010), and esophageal squamous carcinoma cells (Shiozaki et al., 2014). The gene discussed is SLC12A2; the disease is lung adenocarcinoma.