SLC12A2 and central nervous system cancer: In our study, we reported here that NKCC1 protein activity constitutes an important K+ (Rb+) influx mechanism in mouse glioma GL26 cells (~60% of total Rb+ influx) and SB28-GFP cells (~20% of total Rb+ influx) either under basal homeostatic conditions or in response to osmotic stress-induced cell shrinkage.