IL6 and preterm premature rupture of the membranes: It has been reported that the concentration of IL-6 is increased in the amniotic fluid (Romero et al., 1990), cervical vaginal fluid (Lockwood et al., 1994, 2010), fetal membranes (Santhanam et al., 1991), decidua (Lockwood et al., 2010), myometrium (Rauk et al., 2001), and cervix in PTB and pPROM (Chai et al., 2012), both in cases of microbial invasion of the intraamniotic cavity (MIAC) as well as in the absence of infection (Prins et al., 2012).