CFTR and cystic fibrosis: A number of studies have indicated macro- and microvascular endothelial perturbation in people with CF (Romano et al., 2001; Solic et al., 2005; Poore et al., 2013; Rodriguez-Miguelez et al., 2016; Vizzardi et al., 2019) that may be associated with defective endothelial CFTR function (Noe et al., 2009; Brown et al., 2014; Peters et al., 2015; Totani et al., 2017).