Increased circulating levels of von Willebrand factor (vWF) and tissue plasminogen activator (tPA), indicative of endothelial damage and altered hemostasis (Romano et al., 2001), and reduced flow-mediated dilation of the brachial artery, which was associated with more severe airway disease and symptomatic of reduced NO availability (Poore et al., 2013), were reported in CF. Here, PLAT is linked to cystic fibrosis.