PRKG1 and cardiac hypertrophy: Multiple strategies of PKG activation have proven to be cardioprotective in response to various pathological stimuli: inhibition of PDE5 or PDE9 reduced cardiac hypertrophy and improved function following left ventricular pressure overload (PO) induced by TAC (Takimoto et al., 2005; Nagayama et al., 2009; Lee et al., 2015).