MYBPC3 and hypertrophic cardiomyopathy: Mice with mutations in MYBPC3 (cardiac myosin-binding protein C) and in MYH7 (β-myosin heavy) forms of hypertrophic cardiomyopathy (HCM) present with an accumulation of autophagic vacuoles, suggesting impaired autophagic flux (Schlossarek et al., 2012; Song et al., 2014; Carrier et al., 2015; Singh et al., 2017).