Increased β-catenin/Tcf transcriptional activity has been detected in the circulation, along with increased protein levels of β-catenin and enhanced DNA-binding activity of β-catenin/TCF in the skeletal muscle of DMD patients, suggestive of negative effects of activation of the canonical Wnt signaling pathway in DMD (Liu et al., 2016). Here, HNF4A is linked to Duchenne muscular dystrophy.