LMNA and lipodystrophy: Mutations in the LMNA gene, encoding lamin A and lamin C, cause a wide range of diseases: Emery-Dreifuss muscular dystrophy (EDMD) types 2 and 3, limb girdle muscular dystrophy (LGMD) type 1B, cardiomyopathy, lipodystrophies, peripheral neuropathies, and progeria syndromes.