Specifically, in a study to develop a therapeutic strategy for osteoarthritis, Que was shown to increase expression levels of SIRT1, PGC-1α, NRF1 and NFR2, TFAM, and phospho-AMPK α in osteoarthritis rats, confirming the hypothesis that Que might act via the AMPK/SIRT1 signaling pathway (Qiu et al., 2018). The gene discussed is NRF1; the disease is osteoarthritis.