CASP1 and ischemia: Nevertheless, our findings overlap but are distinct from a previous study, which demonstrated that RLX could attenuate caspase-1 activity in an in vivo model of ischemia/reperfusion injury via an eNOS-dependent mechanism (Valle Raleigh et al., 2017), in which the direct involvement of the NLRP3 inflammasome was not provided (Valle Raleigh et al., 2017).