CLDN2 and pancreatitis: Wolthers et al. (2017) found associations with fourteen SNPs in the theunc-51-like kinase 2 (ULK2) gene (highest association with rs281366) and one SNP in G-protein signaling 6 (RGS6) gene (rs17179470), nuclear factor of activated T cells 2 (NFATC2, rs62228256), pancreatic secretory trypsin inhibitor (SPINK1, rs17107315), chymotrypsin C (CTRC, rs10436957), and Claudin-2 (CLDN2, rs4409525) (Wolthers et al., 2019). The proteases cationic and anionic (PRSS1-PRSS2, rs13228878, and rs10273639) reduced the risk of pancreatitis (Wolthers et al., 2019).