SLC22A2 and toxicity: Variants in ERCC1 (rs3212986) (Khrunin et al., 2010; Tzvetkov et al., 2011), EPHX1 (rs1051740) (Khrunin et al., 2014), organic cation transporter-2 (OCT2) (rs596881) and CTR1 (rs12686377 and rs7851395) (Chang et al., 2017) have been associated with a reduced risk of renal toxicity in adult patients.