A genetic variant (rs1872328) in Acylphosphatase 2 (ACYP2), coding for a protein thought to be responsible for hair cell development, was found to be significantly associated with hearing loss in pediatric patients treated with cisplatin for embryonal tumors (Xu et al., 2015) and osteosarcomas (Vos et al., 2016). This evidence concerns the gene ACYP2 and osteosarcoma.