AGT and cardiac hypertrophy: AT1R-induced cardiac hypertrophy might be dependent on the activation of G-protein but not of β-arrestin, since β-arrestin biased agonist [Sar1,Ile4,Ile8]-Ang II (SII-Ang II) stimulation of AT1Rs did not induce hypertrophy in neonatal ventricular cardiomyocytes (Smith et al., 2011).