As such, the PD-0E7-mediated induction of PGC-1α could be a strategic chance not only to boost the oxidative phosphorylation, that restores the ATP levels, and to reduce oxidative stress, but also to favor the mitochondrial proteostasis, which is impaired in aging and in neurodegenerative disease (Leal et al., 2013). Here, PPARGC1A is linked to neurodegenerative disease.