It has been recently also observed that cerebral organoids generated from PITRM1−/− human induced pluripotent stem cells display increased APP levels and Aβ42/Aβ40 ratio, as well as pathological features of AD, including protein aggregation, tau hyperphosphorylation, and neuronal death (Pérez et al., 2020). The gene discussed is APP; the disease is Alzheimer disease.