Prevention of sDPP4-induced endothelial dysfunction in mice (Romacho et al., 2016)Anti-oxidant effects in STZ-induced diabetic rats and LPS-induced sepsis mouse model, respectively (Maeda et al., 2012; Beckers et al., 2017)Reduction of NLRP3/ASC inflammasome activation in db/db mice (Birnbaum et al., 2019)Improved cardiac function in mice (Picatoste et al., 2013). This evidence concerns the gene NLRP3 and endothelial dysfunction.