In this line, it is of interest that viruses with a strong airway epithelial cells tropism such as the respiratory syncytial virus (RSV) activate MDM2 via PI3K/Akt within the few hours after infection, leading to a fast decrease in p53 levels that results in airways epithelial cell survival (Groskreutz et al., 2007). This evidence concerns the gene AKT1 and infection.