Indirect suggestions that SARS-CoV-2 may affect the MDM2/p53 regulatory loop comes from the evidence that similarly to SARS-CoV and MERS-CoV (Chen and Subbarao, 2007; Yuan et al., 2015), the new coronavirus induces low type I IFNs levels, most likely contributing to slow-down the immune response in COVID-19 patients (Li et al., 2020). The gene discussed is MDM2; the disease is COVID-19.