IL6 and early-onset autosomal dominant Alzheimer disease: Several studies on the brain reported that inhibition of IL-6 trans-signaling in microglia and neurons attenuated lipopolysaccharide (LPS)-induced sickness behavior in mice (Burton et al., 2011) and also attenuation of IL-6 trans-signaling mediated neuroinflammation in Alzheimer’s disease models of mice (Escrig et al., 2019).