Chronic activation of the renin angiotensin system (RAS) and increased binding of Angiontesin-II (Ang-II) to the Ang-II type 1 receptor (AT1R) is a crucial mechanism leading to ADAM17 activation, promoting inflammation and hypertension (Xia et al., 2013; Patel et al., 2014; Mukerjee et al., 2019; Xu et al., 2019). The gene discussed is AGT; the disease is hypertensive disorder.