Increase in ADAM17 levels in the paraventricular nucleus (PVN) and subfornical organ (SFO) have been reported to elevate the expression of inflammatory (TNF-α, IL-β, and COX-2) and excitatory mediators, which drive the sympathetic excitation-mediated hypertension and heart failure (Wei et al., 2013; Wei et al., 2015). Here, TNF is linked to Hypertension.