AGT and Hypertension: Later, it was shown that the Ang-II-infusion model of hypertension increased vascular ROS production in vivo (Rajagopalan et al., 1996) and that adenovirus-mediated superoxide dismutase (SOD) overexpression was efficient in preventing this model of hypertension (Laursen et al., 1997; Zimmerman et al., 2004; Lob et al., 2010).