CX3CL1 and Hypertension: Further, the targeted depletion of microglia significantly attenuated neuroinflammation, and glutamate receptor expression in the PVN by attenuating plasma vasopressin levels, kidney norepinephrine concentration, and blood pressure (Shen et al., 2015), thereby proving the possible role of FKN in activation of microglia in Ang-II-induced hypertension in mice (Shi et al., 2010).