ADAM17 and hypertensive disorder: Therefore the ADAM17-mediated shedding of IL-6R generates soluble IL-6R, which binds to IL-6 to form an IL-6/sIL-6R complex which elicits the IL-6 trans signaling-meditated hypertension (Rose-John, 2012; Garbers et al., 2015; Düsterhöft et al., 2019a).