In phenotypic clusters of NERD, subtype 4 patients (NERD with urticaria) would need omalizumab as an effective option, which can inhibit activated basophils and mast cells, the key elements of NERD and urticaria (Lee et al., 2017); subtype 2 patients with severe eosinophilia may need anti-IL-5 as a first option. Here, IL5 is linked to urticaria.