SIRT1 and liver dysplastic nodule: Transcriptional factor FoxO1 is regulated by Sirt1 and plays a role in anti-oxidative stress in DN (Wu et al., 2012), and Sirt1 inhibits the TGFβ/Smad pathway by deacetylating Smad2/3/4/7 (Garcia-Vizcaino et al., 2017; Wang et al., 2018).