CFTR and cystic fibrosis: LXA4 and RvD1 activate CFTR-independent Cl- efflux and inhibit Na+ reabsorption, thus restoring the airway surface hydration (ASL) in CF bronchial epithelia (Verriere et al., 2012; Al-Alawi et al., 2014; Higgins et al., 2016; Ringholz et al., 2018).