TP63 and cystic fibrosis: In primary CF bronchial epithelial cells from F508del/F508del patients infected in vitro with P. aeruginosa, RvD1 upregulates the expression of genes that promote cell survival, such as tumor protein 63 (TP63), opioid receptor μ 1 (OPRM1), and aurora kinase B (AURKB), while it diminishes inflammatory genes, like CCL5 (Isopi et al., 2020).