An example of this version of hybrid-SELEX was utilized to generate the aptamers HL-1 and HL-2 to target the Maver-1 B-cell lymphoma line and negatively selected against the Jeko-1 mantle cell lymphoma line, followed by subsequent positive selection with immunoglobulin lambda-like polypeptide 5—a gold standard biomarker for B cell lymphoma diagnosis (Li et al., 2017). Here, IGLL5 is linked to B-cell non-Hodgkin lymphoma.