According to the consensus of Chinese kidney disease experts, after subcutaneous injection of rhEPO reached weekly 300 IU/kg or intravenous injection of 500IU/kg for four months, it still could not reach or maintain the target value, which was called EPO resistance (Consensus expert Group on diagnosis and treatment of Renal anemia, N. B. o. C. M. A, 2018). The gene discussed is EPO; the disease is kidney disorder.