In psoriasis, TLRs play a vital role as innate immune responses through activation of TLR7 and TLR9 and also the secretion of interleukin-23 (IL-23) via autoimmune plasmacytoid dendritic cell activation which releases interferon-a, that further signals Tip-DC (tumor necrosis factor-a and inducible nitric oxide synthase-producing dendritic cell) activation (Yamamoto, 2015). Here, TNF is linked to psoriasis.