ADSL and cystic fibrosis: On the other hand, unfavorable circumstances for AMPs actions as abnormal salt concentration or acidification, and inactivation by proteases, in ASL of CF patients (Figure 1), have been shown to inactivate AMPs bactericidal functions which may explain increased airway infections (Bals et al., 2001; Lecaille et al., 2016; Simonin et al., 2019).