Recent studies have shown that there are many other natural products that can alleviate CKD progression by regulating RAS, Smad2/3-TGFβRI, TGF-β/Smad signaling pathway, and the Wnt/β-catenin pathway (Chen et al., 2018a; Chen et al., 2018b). This evidence concerns the gene TGFB1 and chronic kidney disease.