TNF and Sepsis: Downregulates expression of inflammatory cytokines stimulated by Pam3CSK4 and activating MAPK, PI3K/Akt and other pathways (Li T. T. et al., 2020). Reduces TNF-α, IL-6 and IL-10 level of mice with sepsis, prevents the neutrophils from infiltrating the lung and kidney, inhibit Th1/Th2, Th17 and Tregs balance (Zhang et al., 2006; Chen et al., 2018).