Previously, by means of long-time (120 min) decoction, we successfully removed the acute toxicity of Bai-fu-pian (Bfp), another kind of Fu-zi, and demonstrated unaltered therapeutic efficacy of detoxified Bfp (dBfp) on rheumatoid arthritis (Tong et al., 2013). The gene discussed is RNF112; the disease is rheumatoid arthritis.