The HSPB1 rs2868370 was correlated with progression free survival in NSCLC [Additive model: p=0.012, OR=1.94, 95%CI, (1.16-3.25); Dominant model: p=0.033, OR=1.89, 95%CI, (1.05–3.37)], SCLC [Additive model: p=0.030, OR=0.30, 95%CI, (0.10–0.89); Dominant model: p=0.037, OR=0.28, 95%CI, (0.09–0.92)] and smoking patients [Additive model: p=0.021, OR=2.36, 95%CI, (1.14–4.89); Dominant model: p=0.021, OR=2.65, 95%CI, (1.16–6.06)]. Here, HSPB1 is linked to small cell lung carcinoma.