The inhibition of the inflammatory response exerted by HEBP in DNBS- and DSS-induced colitis is most probably due to the presence of the phenolic compounds in the extract, which directly or indirectly prevent the activated inflammatory pathways: TLR-4, NF-κB p65, COX-2, or IL-17, thus contributing to restoring the intestinal homeostasis. The gene discussed is TLR4; the disease is colitis.