APOE and Alzheimer disease: Combining information (multimodal) from different types of neuroimaging (structural and functional) with genotype (APOE) or biochemical (CSF) information, as do sMRI, AV45-PET, FDG-PET, DTI, and rs-fMRI, can help to improve diagnostic performance for AD or MCI compared with single-modality methods (Zhang et al., 2011; Young et al., 2013; Schouten et al., 2016; Wei et al., 2016; Gupta et al., 2019a).