Many studies have shown that AGEs are important in neurodegenerative diseases (Li J. et al., 2012; Nenna et al., 2015), while in vitro and in vivo studies have demonstrated the potential of RAGE as a receptor for AGE and as a therapeutic target in neurodegeneration (Sparvero et al., 2009; Deane et al., 2012; Nasser et al., 2015; Ray et al., 2016). This evidence concerns the gene AGER and neurodegenerative disease.