Tau-targeting imaging probes such as [18F]-THK-5351, [18F]-THK-5117, and [18F]-AV-1451 show a high uptake in the patients’ cortex (Harada et al., 2015; Lemoine et al., 2015; Passamonti et al., 2017; Kobayashi et al., 2018; Valotassiou et al., 2018), which means that they can accurately detect NFTs, thus helping in the early diagnosis of AD. Here, MAPT is linked to Alzheimer disease.