Commensurate with mutant protein toxicity, wild-type GARS1 overexpression in CMT2D mice has no discernible rescue effect on neuromuscular pathologies, while the increased dosage of disease-causing Gars alleles causes more severe neuropathy (Motley et al., 2011). The gene discussed is GARS1; the disease is Charcot-Marie-Tooth disease type 2D.