Neuropathy-associated GARS1 mutations have been shown to impair GlyRS localization in neuron-like cell lines (Antonellis et al., 2006; Nangle et al., 2007), which could cause build-up in the soma, although, once again, if this were the cause of increased GlyRS levels then it would probably not be so selectively upregulated. This evidence concerns the gene GARS1 and neuropathy.