It was found that the TRAIL-related signaling pathway may also be related to the pathophysiological change in non-neoplastic diseases, such as diabetes (Bossi et al., 2015), atherosclerosis (Michowitz et al., 2005), rheumatoid arthritis (Dessein et al., 2015), pulmonary hypertension (Lawrie, 2014), and viral hepatitis (Mundt et al., 2005). Here, TNFSF10 is linked to neoplasm.