Interestingly, MMP-14 has been proposed as an activator of latent MMP-2 in conjunction with tissue inhibitors of metalloproteinase 2 (TIMP-2) for degradation of extracellular matrix and promotion of cancer invasion and metastasis (Nishida et al., 2008; Sato and Takino, 2010). Here, TIMP2 is linked to cancer.