MMP14 and neoplasm: In a multivariate logistic regression model, both plasma and tumor-secreted levels of MMP-14 remain independently associated with having a surgical outcome of STR (plasma MMP-14 OR = 5.43, 95% CI = 1.10–26.86, P = 0.038; secreted MMP-14 OR = 1.27, 95% CI = 1.05–1.55, P = 0.016), when patient age, gender and tumor size were taken into account (Supplementary Table S2).