A comparison of the various diagnostic systems’ predictive powers demonstrated that MMP-14 activity (area under the curve based on receiver-operating curves, ROC-AUC = 0.926) exceeded that of either tumor growth rate (ROC-AUC = 0.625), tumor volume (ROC-AUC = 0.701), the level of plasma MMP-14 (ROC-AUC = 0.807) or tumor secreted MMP-14 (ROC-AUC = 0.831, Figure 5C). This evidence concerns the gene MMP14 and neoplasm.