Interestingly, other authors showed that the presence of LRRK2 in the core of LBs was higher in the SNpc than in the locus coeruleus of brains obtained from sporadic PD patients, but the percentage of LBs with detectable LRRK2 was significantly higher in both the brain areas of patients carrying the G2019S LRRK2 mutation (Vitte et al., 2010). This evidence concerns the gene LRRK2 and Parkinson disease.