LRRK2 and Parkinson disease: A particular interest has grown around the gene encoding leucine-rich repeat kinase (LRRK2), localized in the PARK8 locus, because its mutations can account for approximately 4% of all familial PD cases, representing the most frequent genetic cause of PD, and can be also identified in approximately 1% of sporadic cases (Healy et al., 2008).