LRRK2 and synucleinopathy: Indeed, the coexpression of LRRK2 and α-syn genes was not followed by changes in the extent of the α-synucleinopathy or α-syn phosphorylation state (Herzig et al., 2012), and the overexpression of human G2019S LRRK2 did not modify the α-synucleinopathy characterizing A53T α-syn transgenic mice (Daher et al., 2012).