This new vision regarding the molecular mechanisms underlying the differential role of corticosteroids, namely MP, on amino-acid transmitters release, together with the fact that hippocampal neurons abundantly express both MRs and GRs (Karst et al., 2005; Joëls et al., 2012), may impact on the rationale for designing new strategies for better treatment of pathological conditions affecting the hippocampus, specifically drug-refractory epilepsy, post-traumatic stress, memory deficits and neurodegenerative diseases. Here, BCL2A1 is linked to epilepsy.